Fine Organic Chemistry

Fine organic chemistry for custom synthesis :

• base and/or sugar modified nucleoside analogues
• mono-, di- and triphosphate nucleoside analogues
• phosphoramidites, di-nucleotides
• mono & oligosaccharides
  • iminosugars
  • sugar phosphates
  • unnatural sugars
  • saccharidic antigens
• heterobase analogues
  • synthesis of sophisticated heterocyclic compounds (purine, pyrimidine, imidazole, thiophene, thiazole, pyrazole, quinoline, steroids…, including phosphorus and fluorine chemistry)
• Peptides (classical, non-canonical, pseudo, stapled, cyclic-peptides)
• TPD / PROTACs, ADC linkers
• mg to 50-100g synthesis of NCEs, building blocks, scaffolds, intermediates, reference products, drug metabolites, impurities….
• collaboration with preferred external partners for 20g to Kg lab scale-up optimization and synthesis

Fine organic chemistry and optimization processes in other fields:

• nucleoside / nucleotide analogues (base and/or sugar modified analogues, phosphoramidites) as diagnostic or research tools
• fluorescent dyes for diagnostic applications
• optimization of small molecules as diagnostic kit reagents