Medicinal Chemistry

Medicinal chemistry in drug discovery:

  • bibliographic and IP research, analysis of patent environment
  • hit to lead work,
  • lead optimization,
  • small focused library sets (10-50 compounds),
  • interpretation of SAR and biological data,
  • medchem services with preferred external partners including molecular modeling, physical and biological properties, early ADMET and pharmacokinetic studies, solubility screening… ,
  • ideas and implementation of nucleotide prodrug approaches,
  • proposition and initiation of back-up strategies,
  • custom synthesis that typically includes:
    • synthesis of building blocks, scaffolds, intermediates, reference products, competitor compounds, metabolites, impurities…
    • synthesis route scouting and design for mg to 20g
    • preferred external partners for scale-up development for 20g to Kg lab (GMP or non GMP)