Medicinal chemistry in drug discovery:
- bibliographic and IP research, analysis of patent environment for small molecules, peptides, sugars, PROTACs
- Hit to Lead optimization,
- Lead generation and optimization,
- drug candidate selection
- small focused library sets (10-100 compounds),
- interpretation of SAR and biological data,
- medchem services with preferred external partners including physicochemical and in vitro ADME properties, drug-like properties, PK/PD correlation, dose range finding, safety/tox evaluation… ,
- ideas and implementation of nucleotide prodrug approaches,
- proposition and initiation of back-up strategies,
- custom synthesis that typically includes:
- synthesis of building blocks, scaffolds, intermediates, reference products, metabolites, impurities…
- synthesis route scouting and design from mg to 100g