Medicinal Chemistry

Medicinal chemistry in drug discovery:

• bibliographic and IP research, analysis of patent environment for small molecules, peptides, sugars, PROTACs
• Hit to Lead optimization,
• Lead generation  and optimization,
• drug candidate selection
• small focused library sets (10-100 compounds),
• interpretation of SAR and biological data,
• medchem services with preferred external partners including physicochemical and in vitro ADME properties, drug-like properties, PK/PD correlation, dose range finding, safety/tox evaluation… ,
• ideas and implementation of nucleotide prodrug approaches,
• proposition and initiation of back-up strategies,
• custom synthesis that typically includes:
  • synthesis of building blocks, scaffolds, intermediates, reference products, metabolites, impurities…
  • synthesis route scouting and design from mg to 100g